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The objective of this How-To Guide is to outline methods for identifying the critical assets and functions within buildings, determining the threats to those assets, and assessing the vulnerabilities associated with those threats. Based on those considerations, the methods presented in this How-To Guide provide a means to assess the risk to the assets and to make risk-based decisions on how to mitigate those risks. The scope of the methods includes reducing physical damage to structural and non-structural components of buildings and related infrastructure, and reducing resultant casualties during conventional bomb attacks, as well as chemical, biological, and radiological (CBR) agents. This document is written as a How-To Guide. It presents five steps and multiple tasks within each step that will lead you through a process for conducting a risk assessment and selecting mitigation options. It discusses what information is required to conduct a risk assessment, how and where to obtain it, and how to use it to calculate a risk score against each selected threat.